Thallium is a highly toxic element and one of the key metal ions that need to be dealt with urgently in the smelting industry. In this paper，a high-efficiency thallium removal material based on carbon disulfide modified polyacrylamide is developed，which excellent stability is endowed by its three-dimensional cross-linked network structure. By exploring the thallium removal performance of the material under different conditions，the optimal operating conditions are determined: pH = 9，the dosage of the agent is 400 mg /L，the reaction time is 30 min，the reaction temperature is 25 ~ 35 ℃，and the adsorption mechanism of thallium ions in water by the thallium removal material is mainly chemisorption. On this basis，the industrial application research on thallium removal materials is carried out，and the results show that the material has excellent thallium removal performance and can make thallium-containing wastewater stably meet the discharge standards stipulated by the state and local governments. As a new type of thallium adsorption polymer material，carbon disulfide modified polyacrylamide polymer material has low preparation cost，significant safety， environmental protection and economic benefits，and is expected to play an important role in the field of thallium removal from smelting wastewater.