As an important strategic mineral resource in China，the comprehensive utilization of vanadium titanomagnetite is facing more and more severe challenges，and how to effectively develop it has become an urgent task at present. The mass fractions of TFe and TiO2 in a low-grade vanadium titanomagnetite are 11. 83% and 2. 77% respectively. Except for iron， vanadium and titanium，other elements of valuable elements have not reached the level of comprehensive utilization. Therefore，based on the characteristic nature of the mine，the dry magnetic separation waste disposal，wet magnetic separation waste disposal and multi-stage waste disposal conditions are tested，and a reasonable waste disposal process and operation parameters are formulated. The results show that the mineral composition of the mine is complex，and the metal minerals are mainly 12. 46% titanomagnetite and 3. 19% ilmenite，as well as a small amount of pyrrhotite， hematite，magnesium-aluminum spinel and chalcopyrite. Gangue minerals are mainly feldspar，diopside，chlorite，etc. ; Ti is mainly in the form of ilmenite，titanomagnetite and vinyl，and V is mostly deposited in titanomagnetite. The optimal technological process of pre-selection and waste ore discarding: the raw ore is crushed to a particle size of 0 ~ 10 mm，and the dry magnetic separation discarding tailings is carried out under the conditions of tangential velocity of 1. 2 m/s and magnetic field strength of 3 500 GS. The obtained coarse concentrate crushing is further crushed to a particle size of ＜ 3 mm and wet selection is performed at a magnetic field strength of 3 500 GS. Finally，the yield of waste ore discarding concentrate is 44. 30% ，the mass fraction and recovery rate of TFe are 19. 44% and 77. 31% ，respectively，and the mass fraction and recovery rate of TiO2 are 4. 64% and 75. 30% ，respectively. Through this process，the waste rock with a yield of 55. 70% ，TFe and TiO2 mass fractions of 4. 54% and 1. 21% can be discarded，respectively，and the waste ore throwing effect is good，and the grinding energy consumption is reduced and the grade is improved，which is conducive to the subsequent separation operation. The experimental method can provide a reference for the development and utilization of similar resources，and at the same time prove the feasibility and necessity of pre-selection and waste ore discarding technology for pretreatment of low-grade vanadium titanomagnetite grinding operations.