In recent years, many sintering plants have experienced vibration problems in the flue between the main exhaust fan outlet and sinter inlet. In order to solve such problems, the influence of different arrangement forms of the below branch pipe of the sintering machine on the temperature, pressure and flow rate of the exhaust air in the large flue is analyzed; the influence on the flue gas layout between the outlet of the main exhaust fan and the desulfurization inlet on the airflow in the flue is analyzed; the influence of the operation of the fan on the air flow system in the unstable area of its performance curve is analyzed; and combined with the on-site commissioning data of some sintering machines, some specific analysis and research are carried out. The results show that the form of flue design between the main exhaust fan outlet and desulfurization inlet, the sintering operation condition with high negative pressure and low air volume can cause the flue vibration at the outlet of the main exhaust fan. By optimizing the flue design form and making the sintering production under suitable working conditions, the vibration of the flue outlet of the main exhaust fan can be reduced or eliminated.