Yandicoogina and Brazilian ore are imported minerals used on a large scale by domestic iron and steel enterprises. In order to reduce the production cost before iron, increasing the proportion of cheap Yandicoogina in sintering production has become the focus of attention of major iron and steel enterprises. Based on the raw material conditions of an iron and steel company, the effect of Yandicoogina substitution of Brazilian ore on mixture properties and yield and quality indexes of sintering process is studied by sinter pot test system. The results show that after the replacement of Brazilian ore by Yandicoogina, the medium grain size of the sintered mixture decreases and the air permeability index decreases slightly, and the best proportion of the ore to replace the sintering of Brazilian ore is 23.81%, the yield of the resulting sinter is 72.03%, the drum strength is 67.07%, and the solid fuel consumption is 69.56 kg/t. Compared with the benchmark ore blending scheme, the drum strength and yield are increased by 3.31% and 0.40%, respectively. The microstructure and phase analysis of sinter show that the appropriate substitution of Yandicoogina (≤23.81%) will improve the cementation state of iron ore particles in the pores of sinter introduced by the binder phase and increase the strength of sinter. An excessively high substitution ratio (>23.81%) will reduce the content of adhesive powder in the mixture and the temperature of the bed material, resulting in insufficient binder content and a decrease in sinter strength.