In order to realize the high-value utilization of zinc-containing dust and sludge, the zinc hypoxide volatiled from the pyrometallurgy of zinc-containing dust and sludge is used as raw material, and the research on preparation of zinc sulfate by sulfuric acid leaching zinc hypoxide is lunched. The results show that, under the conditions of sulfuric acid mass fraction of 22.42%, leaching time of 20 min, liquid-solid ratio of 2.5:1 and stirring speed of 300 r/min, the mass fraction of Zn in the residue decreases from 61.17% to 2.61%, the mass fraction of Pb increases from 5.86% to 34.24%, the mass concentration of Zn ions in zinc sulfate solution is as high as 243.01 g/L, and the mass concentration of Pb ions reduces to 1.50 g/L. The zinc sulfate solution obtained by the test obtains zinc sulfate products with purity greater than 99% under the conditions of the crystallization temperature of 20 °C and the crystallization time of 60 min, while the prepared zinc sulfate products meet the quality standards of feed additive zinc sulfate.