Aiming at the problem that semi-dry sintering desulfurization ash is difficult to be comprehensively utilized due to complex composition and high CaSO₃ content, in this paper, based on the idea of multi-source collaborative utilization of solid wastes, high value-added lightweight and energy-saving wall materials are prepared with semi-dry sintering desulfurization ash and fly ash as the main raw materials under non-autoclaved curing conditions, and the effects of raw material ratio, fly ash fineness, initial curing temperature, type and dosage of activator on the strength and performance of the product are investigated. The results show that when the mass ratio of fly ash, semi-dry sintering desulfurization ash, lime and cement clinker is 40:40: 5: 15, the amount of glass fiber and triethanolamine is 1% and 0.06%, respectively, after initial curing at 40 ℃ for 7 days and subsequent natural curing, the lightweight wall material with a density of 803 kg/m³ and a compressive strength of 8. 64 MPa for 28 days can be obtained, and the main performance indicators of the material meet the requirements of "Insulation Strips for Building Partition Walls" (GB/T 23450—2009). This process does not require pre-oxidation treatment of semi-dry process desulfurization ash, which provides technical support for its simple and high-value utilization.