The inertia cone crusher is a kind of efficient fine crushing equipment. In order to improve the crushing performance of the inertia cone crusher, the irregular shape of ore is considered, the material particle bonding model is constructed. The simulation research on the crushing process of the crusher is carried out by using the discrete element software (EDEM), and the reason of the uneven particle flow in the lower part of the crushing area is analyzed. In addition, the orthogonal test scheme is designed, the simulation orthogonal test is carried out, the regression analysis on the simulation results is carried out by using MATLAB software, the relationship model with the -5 mm mineral yield as the crushing performance evaluation index and the test factors is established, the test result is optimized by using genetic algorithm. The results show that the crushing performance of the crusher is the best when the speed of the exciter is 25.7 r/s, the eccentric torque is 1 340.6 N·mm, and the feeding quantity is 67.4 kg/s. Therefore, a reference can be provided for the accouplement and optimization of technological parameters of inertia cone crusher.