MEBIOS is a process to optimize the utilization efficiency of return ore in sintering process. According to the materials for sintering of Zenith steel group Co., Ltd, the technology by using MEBIOS process is put forward, and the effect of MEBIOS of different particle sizes is studied through the sintering cup test. The results show that the MEBIOS of +1 mm and +3 mm is beneficial to improve its production and quality of sinter, and the MEBIOS of +1 mm is more conducive to improving the utilization coefficient of sintering machine with an increasing output rate of 6%. However, a certain proportion (20%) of +3 mm return ore used for inlaying is more conducive to improving the quality of sinter, while the drum index, yield, solid fuel consumption and RDI index are comprehensively improved. On the basis of the research, the industrial application of the MEBIOS process device of sintering shows that the temperature of waste gas is increased by 6.1 ℃ and the yield is increased by 2.8% when the proportion of MEBIOS of +3 mm is 25%.