In view of the problem of high air leakage rate of sintering machine, the differential pressure adsorption sealing technology is proposed. The calculation formula of air leakage rate is derived, and the simulation analysis model is built for differential pressure adsorption sealing device. The influence of the differential pressure, the thickness of the elastic sealing plate and its elastic modulus on the air leakage of the differential pressure adsorption sealing technology are studied. The research results show that the thickness of the elastic sealing plate has the greatest influence on the sealing performance, the differential pressure has less influence, and the elastic modulus of the material has the least influence. Simultaneously, the negative pressure adsorption device has the best sealing performance. Finally, the negative pressure adsorption sealing technology is applied to the engineering practice, and through the field test, the leakage air rate is nearly 50% lower than the traditional sealing technology.